A note on NAD+

NAD+ is one of those molecules that sounds like an answer before you know the question. Nicotinamide adenine dinucleotide. A coenzyme present in every living cell, central to energy production, DNA repair, and the way the body manages stress at a level you'll never feel.

We've been asked about it more in the last six months than anything else on the shelf. Worth saying out loud: most of what's been written about NAD+ is enthusiastic past the data. The science is interesting. The marketing has gotten ahead of it.

What the work actually shows

The strongest evidence is in animal models — mice, mostly. Restoring NAD+ levels reverses several markers we associate with aging: mitochondrial function, insulin sensitivity, exercise performance. In humans, the picture is thinner but not absent. Small trials suggest measurable serum increases after supplementation. Whether that translates to the outcomes people care about — energy, sleep, the felt sense of being well — is still being worked out.

Why we carry it anyway

Patience is a stance, not a delay.

We don't carry NAD+ because the literature is settled. We carry it because the downside is small, the mechanism is plausible, and the people who take it tend to report something — a baseline calm, a recovery curve that feels gentler. That's not science. It's the texture of a population that's chosen, over months, to pay attention to itself.

If you take NAD+, take it because you're curious about your own response, not because you've been promised an outcome.

What to read first

The Sinclair group's work at Harvard is the obvious starting point — though read it with one eye on its commercial entanglements. The 2021 *Nature Communications* trial on NR (a precursor) is a sober read. And the Huberman conversation with Charles Brenner is the best thirty minutes of pushback you can get on the field at the moment.

We carry Double Wood's NAD+ because it's the format we use ourselves, and because their third-party testing pages survive the kind of scrutiny we apply to everything before it earns a place here.